Kisspeptin
Emerging Research
Kisspeptin is a family of brain signaling peptides that acts as a master regulator of the reproductive system. It sends a strong signal to the brain to produce reproductive hormones, making it essential for puberty initiation, fertility, and reproductive function. Research explores its therapeutic potential for infertility, low libido, and reproductive disorders.
How it works
Kisspeptin binds to GPR54/KISS1R receptors on GnRH neurons in the hypothalamus, triggering pulsatile release of GnRH. This stimulates the pituitary gland to release LH and FSH (the hormones that drive testosterone and estrogen production), which in turn promote reproductive function.
Key benefits
- ✓Stimulates natural production of reproductive hormones (LH/FSH)
- ✓Supports restoration of natural testosterone levels
- ✓May improve fertility outcomes in both men and women
- ✓Supports sexual function and libido, particularly in people with low hormone levels
Protocols
| Protocol | Dose | Frequency |
|---|---|---|
| Gonadotropin stimulation | 100-200mcg | Single dose or 2-3x/week |
| Fertility support (KP-54) | 0.4-1.0 nmol/kg (50-150mcg) | As directed by physician |
| Sexual function | 1 nmol/kg/h | 75 min IV infusion (clinical) |
| Research protocols | 0.3-10 nmol/kg | Variable by protocol |
Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.
What to expect
Potential improvements in sexual function and libido
What to know
- ⚠Use sterile injection technique to prevent infection
- ⚠Avoid daily administration. Causes desensitization with repeated use
- ⚠Recommended frequency: 2-3x per week maximum
- ⚠May cause cardiovascular effects (blood vessel narrowing). Use caution with heart disease
- ⚠Not recommended during pregnancy or breastfeeding
- ⚠Consult reproductive endocrinologist for fertility applications
- ⚠Monitor for signs of ovarian hyperstimulation in women