MOTS-c
Extensively Studied
MOTS-c is a peptide produced by your mitochondria. It acts as a hormone-like signal that helps regulate your metabolism, enhance insulin sensitivity, and promote longevity. MOTS-c works through a key energy-sensing pathway (AMPK) and can move into cell nuclei during stress to activate protective genes.
How it works
MOTS-c activates AMPK, your body's master energy sensor, which triggers a cascade of metabolic improvements: better blood sugar regulation, increased fat burning, and improved mitochondrial efficiency. When your cells are under metabolic stress, MOTS-c moves into the nucleus and activates stress-protection genes that boost antioxidant defenses and help cells adapt. This is why it shows benefits for both metabolic health and exercise performance.
Key benefits
- ✓Improves insulin sensitivity and blood sugar regulation
- ✓Activates AMPK, your body's master energy sensor
- ✓Supports mitochondrial health and energy production
- ✓Enhances exercise performance and recovery
- ✓Potential longevity and anti-aging benefits
Related goals
Protocols
| Protocol | Dose | Frequency |
|---|---|---|
| Metabolic health | 5-10mg | Once daily |
| Anti-aging protocol | 15mg | 3x weekly |
| Exercise performance | 10-15mg | Pre-workout |
| Conservative start | 5mg | Once daily |
Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.
What to expect
Your body starts responding better to blood sugar. Energy may improve.
Exercise capacity increases. Insulin sensitivity continues to improve.
Sustained metabolic benefits. Body composition may start shifting.
Full mitochondrial benefits. Your body handles energy more flexibly, switching between fuel sources with ease.
What to know
- ⚠Generally well-tolerated in animal studies with minimal side effects
- ⚠Monitor blood glucose if using diabetes medications; may require dose adjustment
- ⚠Limited long-term human safety data - use with appropriate medical supervision
- ⚠May cause mild injection site reactions (redness, swelling)
- ⚠Not recommended during pregnancy or breastfeeding
- ⚠Prohibited by WADA for competitive athletes (metabolic modulator)