Four things to know · April 15, 2026
CJC-1295 (without DAC)
Modified Growth Releasing Factor 1-29
CJC-1295 without DAC (also called Mod GRF 1-29) is a short-acting peptide that tells your pituitary gland to release more growth hormone.
Noticed in days · Full benefit in weeks
Week 2-4
Typically increased recovery from workouts, reduced soreness, better pumps
Week 4-8
Commonly noticeable improvements in skin quality, minor body composition changes
Week 8-12
More significant lean mass gains, fat loss, and improved joint comfort are typically reported
Week 12+
Continued gradual improvements in body composition and well-being are commonly reported
CJC-1295 without DAC (also called Mod GRF 1-29) is a short-acting peptide that tells your pituitary gland to release more growth hormone. It works with your body's natural rhythm, triggering growth hormone in pulses rather than flooding your system with a constant supply. Because it clears quickly (about 30 minutes), you get a controlled boost without overwhelming the receptors that respond to the signal.
How it works
CJC-1295 attaches to growth hormone-releasing receptors in the pituitary gland, the small gland at the base of your brain that controls growth hormone output. This triggers a signaling chain inside those cells that causes them to release growth hormone in natural pulses, the same way your body does on its own. The short half-life means each dose produces a defined pulse rather than a prolonged elevation.
Key benefits
What it’s been studied for:
- ✓Stimulates growth hormone release while preserving your body's natural pulse pattern
- ✓Well-tolerated with minimal side effects at standard doses
- ✓Short duration reduces the risk of your receptors becoming less responsive over time
- ✓Allows precise control over the timing and size of growth hormone pulses
Regulatory status
Removed from Category 2 in September 2024 but not yet added to Category 1. Not currently scheduled for FDA pharmacy compounding advisory committee review.
Protocols
| Protocol | Dose | Frequency |
|---|---|---|
| General wellness | 100mcg | 2x daily (morning and bedtime) |
| Body Composition | 100-150mcg | 3x daily (morning, post-workout, bedtime) |
| Maximum GH release | 200mcg | 2-3x daily with GHRP |
| Sleep support | 100-200mcg | Once at bedtime |
Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.
What people report
Typically increased recovery from workouts, reduced soreness, better pumps
Commonly noticeable improvements in skin quality, minor body composition changes
More significant lean mass gains, fat loss, and improved joint comfort are typically reported
Continued gradual improvements in body composition and well-being are commonly reported
What to know
- ⚠Temporary facial flushing or warmth after injection is common and fades within 5-10 minutes
- ⚠Well-tolerated at standard doses with minimal reported side effects
- ⚠If you have diabetes, monitor blood sugar closely; growth hormone affects insulin sensitivity
- ⚠Avoid if you have diabetic retinopathy or severe kidney disease
- ⚠Not suitable for anyone with active cancer, as growth hormone can promote cell growth
KEY RESEARCH · 4 PAPERS CITED
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