GHK-Cu
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GHK-Cu

Copper Tripeptide

Category 1Injection · Topical

GHK-Cu is a naturally occurring copper-binding tripeptide that your body produces less of as you age. Between your twenties and your sixties, levels decline by over 60%. It plays a key role in collagen synthesis, tissue repair, and inflammation signaling. Replacing what your body used to make naturally is the core premise of GHK-Cu therapy.

How it works

GHK-Cu binds copper ions and delivers them to cells, activating pathways involved in collagen production, antioxidant defense, and tissue remodeling. Research shows it modulates the expression of over 4,000 genes, many related to wound healing, immune response, and inflammation. It promotes new blood vessel formation and increases production of decorin, a protein essential for skin structure.

Key benefits

  • Reduces systemic inflammation
  • Promotes collagen synthesis and skin regeneration
  • Accelerates wound healing and tissue repair
  • Supports hair growth and thickness
  • Modulates 4,000+ genes related to aging
  • Restores a naturally declining peptide

Related goals

Injection

recommended

Systemic anti-inflammatory, skin improvement everywhere, tissue repair, and hair growth. The injection form delivers GHK-Cu throughout the body, not just where you apply it. This is the form most researchers focus on.

Injection protocols

ProtocolDoseFrequency
Standard anti-aging1-2mgDaily
Tissue repair2-3mgDaily
Hair restoration1-2mgDaily
Anti-inflammatory1-2mgDaily

Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.

What to expect

Days 1-3

Reduced systemic inflammation. Many report feeling noticeably better, improved sleep quality and mood.

Week 1-2

Skin hydration improves across the body. Redness and irritation decrease. Chronic dry skin begins resolving.

Week 2-4

Fine lines fade. Skin texture becomes visibly smoother. Others may start noticing changes.

Month 2-3

Full regenerative effects. Hair thickening becomes visible. Collagen density measurably improved.

What to know

  • Consult a healthcare provider before starting GHK-Cu injections
  • May temporarily increase skin purging (breakouts) in weeks 2-4 before improvement
  • Monitor for injection site reactions
  • Not recommended during pregnancy or breastfeeding
  • Use caution if on blood thinners due to its effect on blood vessel growth

Also available as

Key research

Pickart L et al. · International Journal of Molecular Sciences · 2018
Pickart L et al. · BioMed Research International · 2014
Pickart L et al. · Oxidative Medicine and Cellular Longevity · 2015