Four things to know · April 15, 2026
KPV · Nasal spray
Lysine-Proline-Valine
Nasal KPV delivers anti-inflammatory action directly to the sinus passages for chronic sinusitis and nasal inflammation.
Noticed in days · Full benefit in weeks
Week 1
Typically reduced nasal congestion and sinus pressure.
Week 2-3
Commonly improved breathing and reduced sinus inflammation.
Week 4-6
Significant relief from chronic sinusitis symptoms is commonly reported.
Nasal KPV delivers anti-inflammatory action directly to the sinus passages for chronic sinusitis and nasal inflammation. Targets the source of sinus inflammation without systemic exposure.
Nasal spray protocols
| Protocol | Dose | Frequency |
|---|---|---|
| Chronic sinusitis | 200-400mcg | 1-2x daily |
| Acute sinus inflammation | 400mcg | 2x daily for 1-2 weeks |
Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.
What people report
Typically reduced nasal congestion and sinus pressure.
Commonly improved breathing and reduced sinus inflammation.
Significant relief from chronic sinusitis symptoms is commonly reported.
What to know
- ⚠Do not use if nasal passages are actively infected
- ⚠Monitor for nasal irritation with prolonged use
- ⚠Store in refrigerator after opening
- ⚠Consult healthcare provider if using other nasal medications
Also available as
Systemic anti-inflammatory
The primary route for whole-body anti-inflammatory and immune-modulating effects. KPV injection delivers the peptide systemically for conditions affecting multiple areas, autoimmune support, and broad inflammation reduction.
Full details →OralGut inflammation and IBD/IBS
Oral KPV delivers the peptide directly to the gastrointestinal tract, making it the preferred route for inflammatory bowel disease, IBS, and gut-specific inflammation. Three distinct protocols address different levels of gut inflammation severity.
Full details →TopicalSkin conditions and psoriasis
Topical KPV targets skin inflammation directly. Research shows topical KPV reduced psoriatic markers by 60%. Best for psoriasis, eczema, and localized skin inflammation where systemic treatment is not needed.
Full details →How KPV works
Most anti-inflammatory compounds work on the surface of cells. KPV is small enough to pass through the membrane and reach the nucleus, where it blocks NF-κB, one of the body's main inflammation switches. That inside-out approach is why it's being studied for conditions where inflammation is deep and persistent.
Key benefits
- ✓Reduces inflammation from inside the cell, not just the surface
- ✓Antimicrobial action alongside the anti-inflammatory effect
- ✓No skin pigmentation changes (unlike the full hormone it comes from)
- ✓Particularly promising for gut and skin inflammation
Regulatory status
Category 2. The FDA's pharmacy compounding advisory committee is scheduled to review KPV on July 23, 2026, for potential addition to the 503A bulks list. The uses under review: wound healing and inflammatory conditions.
KEY RESEARCH · 6 PAPERS CITED
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