← KPV overview
KPV
Oral
Gut inflammation and IBD/IBS
Early research
First effectsWeek 1
Full benefitsWeek 6-8
Oral KPV delivers the peptide directly to the gastrointestinal tract, making it the preferred route for inflammatory bowel disease, IBS, and gut-specific inflammation. Three distinct protocols address different levels of gut inflammation severity.
Oral protocols
| Protocol | Dose | Frequency |
|---|---|---|
| IBD/IBS support | 500mcg-1mg | 1-2x daily |
| Mild gut inflammation | 250-500mcg | Once daily |
| Acute flares | 1mg | 2x daily for 1-2 weeks, then reduce |
Protocols are from published research literature. This is not medical advice. Dosing should be determined by a licensed clinician.
What to expect
Week 1
Reduced GI discomfort and bloating.
Week 2-3
Improved bowel regularity, reduced gut inflammation.
Week 4-6
Significant improvement in IBD/IBS symptoms.
Week 6-8
Sustained gut health improvements.
What to know
- ⚠Well tolerated orally with minimal side effects
- ⚠Take on empty stomach for optimal absorption
- ⚠Does not cause immunosuppression
- ⚠Consult healthcare provider if on other IBD medications
Other ways to take KPV
How KPV works
Enters cells and inhibits inflammatory pathways at the nuclear level, particularly NF-κB (a key inflammation switch) signaling
Key research
Dalmasso G et al. · Gastroenterology · 2008
Kannengiesser K et al. · Inflammatory Bowel Diseases · 2008
Xiao B et al. · Molecular Therapy · 2017
Land SC · International Journal of Physiology, Pathophysiology and Pharmacology · 2012
Viennois E et al. · Cellular and Molecular Gastroenterology and Hepatology · 2016
Cutuli M et al. · Journal of Leukocyte Biology · 2000